Added August 25, 2008
Lancet. 2008 Jul 12;372(9633):117-26. Adjuvant pegylated interferon alfa-2b for stage III melanoma has a significant, sustained effect on recurrence-free survival. Continue reading
Added August 25, 2006
N Engl J Med. 2006 Sep 28;355(13):1307-17.The staging of intermediate-thickness (1.2 to 3.5 mm) primary melanomas according to the results of sentinel-node biopsy provides important prognostic information and identifies patients with nodal metastases whose survivalcan be prolonged by immediate lymphadenectomy. Continue reading
Added April 14, 2005
J Clin Oncol. 2005 Apr 1;23(10):2346-57. Lymphodepleting chemotherapy followed by the transfer of highly avid antitumor lymphocytes can mediate significant tumor regression in heavily pretreated patients with IL-2 refractory metastatic melanoma. Continue reading
Added August 25, 2004
J Clin Oncol. 2004 Jan 1;22(1):53-61. The results from this study, taken in isolation, do not indicate that extended-duration low-dose interferon is significantly better than observation alone in the initial treatment of completely resected high-risk malignant melanoma. Continue reading
Added August 25, 2004
N Engl J Med. 2004 Feb 19;350(8):757-66. A 1-cm margin of excision for melanoma with a poor prognosis (as defined by a tumor thickness of at least 2 mm) is associated with a significantly greater risk of regional recurrence than is a 3-cm margin, but with a similar overallsurvival rate. Continue reading
Added September 3, 2003
Cancer. 2003 Apr 15;97(8):1941-6.The authors concluded that for melanoma less than 2.1-mm thick, a margin of excision of 2 cm is sufficient. A larger margin of 5 cm does not appear to have any impact on either the rate or the time to disease recurrence or on survival. Continue reading
Added August 25, 2001
Lancet. 2001 Sep 15;358(9285):866-9. Patients with melanoma that has spread to the local draining regional lymph nodes tolerate well 3 MU of interferon alpha-2a given subcutaneously three times a week for 3 years, but this treatment does not improve either disease-free or overall survival. Continue reading
Added August 25, 2001
Ann Surg Oncol. 2001 Mar;8(2):101-8.For this group of melanoma patients, a local recurrence is associated with a high mortality rate, a 2-cm margin of excision is safe and ulceration of the primary melanoma is the most significant prognostic factor heralding an increased risk for a local recurrence. Continue reading
Added August 25, 2000
Cancer. 2000 Oct 1;89(7):1495-501. Patients in this category can be treated with a resection margin of 2 cm as safely as with a resection margin of 5 cm. Continue reading
Added September 3, 1998
Lancet. 1998 Mar 14;351(9105):793-6. Node dissection offers increased survival in patients with node metastases only. Sentinel node biopsy may become a tool to identify patients with occult node metastases, who could then undergo node dissection. Continue reading