N Engl J Med. 2010 Apr 8;362(14):1273-81.As compared with gemcitabine alone, cisplatin plus gemcitabine was associated with a significant survival advantage without the addition of substantial toxicity. Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary cancer. Continue reading
Ann Surg. 2010 Dec;252(6):903-12. Surgical resection may provide better survival and lower recurrence rates than RFA for patients with HCC to the Milan criteria. Continue reading
Ann Surg. 2008 Jan;247(1):49-57.PVE is a safe and effective procedure in inducing liver hypertrophy to prevent postresection liver failure due to insufficient liver remnant.
N Engl J Med. 2008 Jul 24;359(4):378-90.In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo.
Ann Surg. 2003 Feb;237(2):208-17. Before elective right hepatectomy, the hypertrophy of FLR induced by PVE had no beneficial effect on the postoperative course in patients with normal liver. In contrast, in patients with chronic liver disease, the hypertrophy of the FLR induced by PVE decreased significantly the rate of postoperative complications. Continue reading
Lancet. 2002 May 18;359(9319):1734-9.Chemoembolisation improved survival of stringently selected patients with unresectable hepatocellular carcinoma. Continue reading
Hepatology. 2001 Jun;33(6):1394-403. Patients with HCC meeting the following criteria: solitary tumor < or = 6.5 cm, or < or = 3 nodules with the largest lesion < or = 4.5 cm and total tumor diameter < or = 8 cm, had survival rates of 90% and 75.2%, at 1 and 5 years, respectively, after OLT versus a 50% 1-year survival for patientswith tumors exceeding these limits (P =.0005). We conclude that the current criteria for OLT based on tumor size may be modestly expanded while still preserving excellent survival after OLT. Continue reading
Ann Surg. 1997 Dec;226(6):704-11; Performing the Pringle maneuver during liver transection resulted in less blood loss and better preservation of liver function in the early postoperative period. This is probably because there was less hemodynamic disturbance induced by the bleeding. Continue reading
N Engl J Med. 1996 Mar 14;334(11):693-9. Liver transplantation is an effective treatment for small, unresectable hepatocellular carcinomas in patients with cirrhosis.
Ann Surg. 1996 Nov;224(5):639-46.Patients with nodal metastasis beyond the pericholedochal nodes should not be considered for curative resection. Tumors staged T4, NO should be included with stage III disease, and resection should be considered. Re-resection of T2 or T3 tumors after simple cholecystectomy is likely to include residual disease and should thus provide the only chance for long-term survival.